Osmania General Hospital (OGH) is one of the oldest hospitals in India located at Afzal Gunj, Hyderabad and is named after its founder – Mir Osman Ali Khan, the last Nizam of Hyderabad. It is run by the Government of Telangana, and is one of the largest in the state. It was built at a construction cost of ?2,00,00,000.

The present hospital building was completed in 1919 on orders of the last Nizam of Hyderabad, Mir Osman Ali Khan. It was designed by British architect Vincent Jerome Esch and Nawab Khan Bahadur Mirza Akbar Baig in Indo-Sarcenic style. In 1926, the wards of the Afzal Gunj hospital were transferred to the new building. The history of the hospital includes Dr. Yusuf Mirza, the 1st RMO (Resident Medical Officer). Dr. K Gopal Rao was one of the team of doctors when started along with the RMO. Names of these doctors are still there at the General Ward entrance. In 2015, the Chief Minister of Telangana, K. Chandrashekhar Rao announced a plan to demolish the building.[2] This sparked outrage among heritage activists, and he immediately retracted the statement